PreClinical Services

SNBL USA is committed to providing clients with quality you expect with your preclinical needs. We are committed to providing service you trust with the turnaround you need.

Nucleic Acid Therapeutics

As a drug class, Nucleic Acid-based Therapeutics represents a diverse spectrum of chemistry, constructs, and delivery options.

Laboratory Services

Blending our strengths, SNBL USA’s laboratory services division represents a powerful resource to extend discovery and development capabilities while still providing superior, individualized service to each client.

Visit SNBL USA at the American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting

Posted on May 14, 2015

SNBL USA will be at the American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting this week in New Orleans. If you are attending ASGCT, the largest gene and cell therapy conference in the world, stop by booth #124. That is where we will be showcasing the molecular biology and stem cell services we offer to support gene therapy studies. See you in New Orleans! American Society of Gene & Cell Therapy 18th Annual Meeting...

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Urinary Biomarkers for Drug-induced Renal Toxicities in Cynomolgus Monkeys

Posted on May 12, 2015

Pre-SOT Abstract: Blood urea nitrogen (BUN) and creatinine (CRN) have been used as biomarkers (BMs) for detecting drug-induced renal toxicities. Since FDA and EMA proposed several BMs in rats, such as urinary protein, albumin (ALB), β2-microglobulin (B2M), clusterin (CLU) and cystatin C (CysC), we examined the availability of these urinary BMs in cynomolgus monkeys. We used 3 renal toxic compounds: gentamicin (GM), cisplatin (CDDP) and puromycin aminonucleoside (PAN). Three cynomolgus monkeys/group (total 9 animals) received GM (sc, 40 mg/kg/day, 7 days), CDDP (iv, 3 mg/kg, single dose) or...

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Pre-SOT Abstract: Comparison of Histopathology Findings in Macaque (Rhesus Vs Cynomolgus)…

Posted on May 10, 2015

Comparison of Histopathology Findings in Macaque (Rhesus Vs Cynomolgus) Tissues and Organs Following a Single Dose Of Irradiation R.Love1, K.Jackson1, R. Manning1, S.Glaza1, T.Beck1, K. Fukuzaki1, and R. Nagata2. 1SNBL USA, Ltd., Everett, WA, USA; 2Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan In continuing efforts to develop and characterize well defined animal models for the acute radiation syndrome under the FDA Animal Rule (21CR314, subpart 1), total body irradiation (TBI) was applied to six cynomolgus macaques (5 to 9 kg) at a total dose of 7.55 Gray (Gy) and to eight...

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