PreClinical Services

SNBL USA is committed to providing clients with quality you expect with your preclinical needs. We are committed to providing service you trust with the turnaround you need.

Nucleic Acid Therapeutics

As a drug class, Nucleic Acid-based Therapeutics represents a diverse spectrum of chemistry, constructs, and delivery options.

Laboratory Services

Blending our strengths, SNBL USA’s laboratory services division represents a powerful resource to extend discovery and development capabilities while still providing superior, individualized service to each client.


Urinary Biomarkers for Drug-induced Renal Toxicities in Cynomolgus Monkeys

Posted on Mar 18, 2015

Urinary Biomarkers for Drug-induced Renal Toxicities in Cynomolgus Monkeys

Pre-SOT Abstract: Blood urea nitrogen (BUN) and creatinine (CRN) have been used as biomarkers (BMs) for detecting drug-induced renal toxicities. Since FDA and EMA proposed several BMs in rats, such as urinary protein, albumin (ALB), β2-microglobulin (B2M), clusterin (CLU) and cystatin C (CysC), we examined the availability of these urinary BMs in cynomolgus monkeys. We used 3 renal toxic compounds: gentamicin (GM), cisplatin (CDDP) and puromycin aminonucleoside (PAN). Three cynomolgus monkeys/group (total 9 animals) received GM (sc, 40 mg/kg/day, 7 days), CDDP (iv, 3 mg/kg, single dose) or...

Read More

Pre-SOT Abstract: Comparison of Histopathology Findings in Macaque (Rhesus Vs Cynomolgus)…

Posted on Mar 10, 2015

Pre-SOT Abstract: Comparison of Histopathology Findings in Macaque (Rhesus Vs Cynomolgus)…

Comparison of Histopathology Findings in Macaque (Rhesus Vs Cynomolgus) Tissues and Organs Following a Single Dose Of Irradiation R.Love1, K.Jackson1, R. Manning1, S.Glaza1, T.Beck1, K. Fukuzaki1, and R. Nagata2. 1SNBL USA, Ltd., Everett, WA, USA; 2Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan In continuing efforts to develop and characterize well defined animal models for the acute radiation syndrome under the FDA Animal Rule (21CR314, subpart 1), total body irradiation (TBI) was applied to six cynomolgus macaques (5 to 9 kg) at a total dose of 7.55 Gray (Gy) and to eight...

Read More

SNBL USA Announces Newly Appointed Experts to Acute Radiation Syndrome (ARS) Advisory Board

Posted on Mar 5, 2015

SNBL USA Announces Newly Appointed Experts to Acute Radiation Syndrome (ARS) Advisory Board

Everett, WA – March 5, 2015 – SNBL USA, the experts in preclinical research, announced today the members of its newly-formed ARS Advisory Board, comprised of leading experts in the field of radiation biology and research. The Advisory Board will serve to provide strategic vision and scientific guidance to SNBL USA’s ARS program. “We are excited and honored to announce the formation of this Board as we broaden our ARS program,” said Dr. Koichiro Fukuzaki, SNBL USA President and CEO. “These distinguished members represent years of technical and scientific expertise, providing...

Read More