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Radiation Biology

 

SNBL USA is in a unique position to perform Acute Radiation Syndrome (ARS) studies, from demonstration of efficacy in representative animal models to pivotal, GLP nonclinical studies under the FDA Animal Rule. Our team is dedicated to research, development and licensure of medical countermeasures (MCMs) aimed at national preparedness.

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Advantages

ARS Advisory Board
Purpose-built bunker and dedicated large animal ARS wing
Custom model development in large and small animals
Organ-specific ARS models in multiple species
Comprehensive and compliant animal welfare program
Flexibility to meet client needs

SNBL USA Owned Clinac

Scientific Resources

Experienced scientists in MCMs and ARS Animal Model Development
Board-certified veterinarians
Board-certified veterinary pathologists
Board-certified clinical pathologist
Study team dedicated exclusively to Radiation Biology
GLP-compliant drug development services in multiple species

Animal Welfare & Compliance

Appropriate supportive care paradigms to meet study objectives
Good Laboratory Practices (GLP)-compliant
PHS OLAW Assurance
AAALAC International Accreditation
IACUC review and approval of study designs and procedures

Technological Resources

Varian Clinac 21EX LINAC

Photon and Electron Energies available

Xstrahl 100 Orthovoltage X-ray Arm

Targeted beam radiation exposure
Superficial low energy X-ray
Selectable energy up to 100 kV
Selectable focal areas for exposure

Rad Source RS-2000 Irradiator

(160kV at 25mA) X-ray Generator
Offers custom animal shielding and variable dose rates
Dose distribution is better than 94% across the field

Siemens SomaTom Scope CT Scanner

Large bore CT Capabilities

Eclipse Treatment Planning System

Advanced Dose calculations
Fast Anisotropic Analytical Algorithm (AAA)

Fenwal Amicus™ Separator with Apheresis capabilities

Scientific Resources

Experienced scientists in MCMs and ARS Animal Model Development
Board-certified veterinarians
Board-certified veterinary pathologists
Board-certified clinical pathologist
Study team dedicated exclusively to Radiation Biology
GLP-compliant drug development services in multiple species

Animal Welfare & Compliance

Appropriate supportive care paradigms to meet study objectives
Good Laboratory Practices (GLP)-compliant
PHS OLAW Assurance
AAALAC International Accreditation
IACUC review and approval of study designs and procedures

Technological Resources

Varian Clinac 21EX LINAC

Photon and Electron Energies available

Xstrahl 100 Orthovoltage X-ray Arm

Targeted beam radiation exposure
Superficial low energy X-ray
Selectable energy up to 100 kV
Selectable focal areas for exposure

Rad Source RS-2000 Irradiator

(160kV at 25mA) X-ray Generator
Offers custom animal shielding and variable dose rates
Dose distribution is better than 94% across the field

Siemens SomaTom Scope CT Scanner

Large bore CT Capabilities

Eclipse Treatment Planning System

Advanced Dose calculations
Fast Anisotropic Analytical Algorithm (AAA)

Fenwal Amicus™ Separator with Apheresis capabilities

Contact our Radiation Biology Experts

Ask questions. We’re here to help.