The continuous infusion of drugs in tethered non-human primates is becoming increasingly important in safety pharmacology and drug development programs. In some cases, the duration of long term studies is limited by how well an intravenous tether infusion system is tolerated by the animals. A program to significantly improve existing hardware and procedures was undertaken to successfully perform a tethered intravenous infusion study on a large number of non-human primates (Macaca fascicularis) for 99 days. A new infusion jacket was developed in conjunction with a commercial vendor that incorporated integrated adjustability and padding to improve fit and decrease irritation to the animal. The implanted catheter was updated to incorporate new design elements to decrease irritation to the vein, provide more secure placement, and increase catheter survivability and ease of replacement. Use of an Electronic Data Capture System (EDCS) and updated processes were implemented so that technicians could focus more on animal care and infusion specific data could be captured electronically. The program resulted in more accurate and consistent data that was easier to interpret. Tolerability of the hardware by the animals was improved and measurements associated with animal welfare were superior to previous systems. There was also a substantial positive impact on the life span of the equipment while also decreasing personnel hours required to perform the infusion procedures.
M. Benedict¹, K. Watson¹, B. Megrath¹, and S. Jacobson¹
¹SNBL USA, Ltd., Everett, WA, USA;